Praziquantel

mankhwala

Praziquantel

Zambiri Zoyambira:

Praziquantel ndi mankhwala okhala ndi mankhwala C 19 H 24 N 2 O 2 . Ndi mankhwala anthelmintic omwe amagwiritsidwa ntchito mwa anthu ndi nyama. Amagwiritsidwa ntchito makamaka pochiza tapeworms ndi flukes. Ndiwothandiza kwambiri polimbana ndi schistosoma japonicum, Chinese liver fluke, ndi Diphyllobothrium latum.

Njira ya mankhwala: C 19 H 24 N 2 O 2

Kulemera kwa molekyulu: 312.406

Nambala ya CAS: 55268-74-1

Nambala ya EINECS: 259-559-6


Tsatanetsatane wa Zamalonda

Zolemba Zamalonda

Physicochemical katundu

Kachulukidwe: 1.22 g/cm3
Malo osungunuka: 136-142 ° C
Malo otentha: 544.1°C
Pothirira: 254.6°C
Mlozera wowoneka bwino: 1.615
Maonekedwe: ufa wonyezimira woyera kapena wosayera

ntchito

Amagwiritsidwa ntchito ngati yotakata sipekitiramu antiparasitic mankhwala kuchiza ndi kupewa likodzo, cysticercosis, paragonimiasis, echinococcosis, fasciococcus, echinococcosis, ndi matenda helminth.

Makhalidwe

Izi ndi zoyera kapena zoyera za crystalline ufa.
Izi zimasungunuka mosavuta mu chloroform, sungunuka mu Mowa, komanso osasungunuka mu ether kapena madzi.

Malo osungunuka

Malo osungunuka a mankhwalawa (General Rule 0612) ndi 136 ~ 141 ℃.

gulu

Mankhwala anthelmintic.

Zizindikiro

Ndi mankhwala olimbana ndi trematodes ndi tapeworms. Ndi oyenera osiyanasiyana likodzo, clonorchiasis, paragonimiasis, fasciolosis, tepiworm matenda ndi cysticercosis.

Pharmacological Action

Izi makamaka zimayambitsa kufa ziwalo ndi kukhetsa likodzo ndi tepiworms mwa wolandirayo kudzera mu zotsatira za 5-HT-like. Zimakhala ndi zotsatira zabwino pa tapeworms akuluakulu komanso osakhwima. Pa nthawi yomweyo, izo zingakhudze kashiamu ayoni permeability mu minofu maselo a nyongolotsi thupi, kuonjezera kuchuluka kwa ayoni kashiamu, ziletsa reuptake wa sarcoplasmic reticulum kashiamu mapampu, kwambiri kuonjezera calcium ayoni zili mu minofu maselo a nyongolotsi. thupi, ndikupangitsa thupi la mphutsi kuti lipuwala ndikugwa.

Kusungirako

Sungani kutali ndi kuwala ndikusunga mu chidebe chosindikizidwa.


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