Methyl 2,2-difluorobenzo[d] [1,3]dioxole-5-carboxylate: Katundu ndi Magwiridwe

Methyl 2,2-difluorobenzo[d] [1,3]dioxole-5-carboxylatendi mankhwala omwe ali ndi mamolekyu a C9H6F2O4 ndi nambala ya CAS 773873-95-3. Amadziwikanso ndi mawu ofanana angapo, monga methyl 2,2-difluoro-1,3-benzodioxole-5-carboxylate, 2,2-difluorobenzodioxole-5-carboxylic acid methyl ester, ndi EOS-61003. Ndi m'gulu la heterocyclic mankhwala ndi mpweya hetero-maatomu okha.

Podzitamandira chiyero cha 98% chocheperako, chigawo chamankhwala ichi ndi njira yosunthika yamafakitale monga mankhwala, agrochemicals, ndi research.This pawiri imagwiritsidwa ntchito ngati chinsinsi chapakatikati pakupanga mankhwala, kupanga zinthu zoteteza mbewu, ndi kafukufuku wasayansi.

M'nkhaniyi, tifotokoza mwatsatanetsatane katundu ndi ntchito ya methyl 2,2-difluorobenzo[d] [1,3]dioxole-5-carboxylate, kutengera zomwe zilipo.

Zakuthupi ndi Zamankhwala

Methyl 2,2-difluorobenzo[d] [1,3]dioxole-5-carboxylate ndi madzi otumbululuka achikasu kapena olimba, kutengera kutentha ndi kuyera. Ili ndi kulemera kwa molekyulu ya 216.14 g/mol ndi kachulukidwe ka 1.5±0.1 g/cm3. Ili ndi malo otentha a 227.4±40.0 °C pa 760 mmHg ndi kung'anima kwa 88.9±22.2 °C. Imakhala ndi mpweya wochepa wa 0.1±0.4 mmHg pa 25°C ndi kusungunuka kwamadzi kochepa kwa 0.31 g/L pa 25°C. Ili ndi chipika P mtengo wa 3.43, kusonyeza kuti imasungunuka kwambiri mu zosungunulira za organic kuposa m'madzi.

Kapangidwe ka methyl 2,2-difluorobenzo[d][1,3]dioxole-5-carboxylate imakhala ndi mphete ya benzene yosakanikirana ndi mphete ya 1,3-dioxole, yokhala ndi maatomu awiri a fluorine ndi gulu la carboxylate lomwe limalumikizidwa ndi mphete ya benzene. . Kukhalapo kwa maatomu a fluorine kumawonjezera kukhazikika komanso kusinthika kwapawiri, komanso lipophilicity ndi bioavailability. Gulu la carboxylate limatha kukhala ngati gulu lochoka kapena nucleophile mosiyanasiyana. Mphete ya 1,3-dioxole imatha kukhala ngati masked glycol kapena dienophile muzochita za cycloaddition.

Chitetezo ndi Kusamalira

Methyl 2,2-difluorobenzo[d][1,3]dioxole-5-carboxylate imayikidwa ngati chinthu chowopsa malinga ndi Global Harmonized System of Classification and Labeling of Chemicals (GHS). Lili ndi ziganizo zotsatirazi zowopsa komanso zodzitetezera:

• H315: Imayambitsa kuyabwa pakhungu

• H319: Imayambitsa kukwiya kwambiri m'maso

• H335: Zingayambitse kupsa mtima

• P261: Pewani kupuma fumbi/fume/gasi/nkhungu/ nthunzi/utsi

• P305+P351+P338: NGATI M’MASO: Sambani mosamala ndi madzi kwa mphindi zingapo. Chotsani magalasi olumikizirana, ngati alipo komanso osavuta kuchita. Pitirizani kutsuka

• P302+P352: NGATI PAKHUMBA: Sambani ndi sopo wambiri ndi madzi

Njira zothandizira methyl 2,2-difluorobenzo[d] [1,3]dioxole-5-carboxylate ndi motere:

• Kukoka mpweya: Ngati mutakowetsedwa, sunthirani wodwalayo ku mpweya wabwino. Ngati kupuma kuli kovuta, perekani mpweya. Ngati simukupuma, perekani mpweya wochita kupanga. Pitani kuchipatala

• Kukhudza khungu: Chotsani zovala zomwe zili ndi kachilombo ndikutsuka khungu ndi sopo ndi madzi. Ngati simukumva bwino, pitani kuchipatala

• Kuyang'ana m'maso: Patulani zikope ndikutsuka ndi madzi oyenda kapena saline wamba. Pitani kuchipatala msanga

• Kudya: Sungunulani, osayambitsa kusanza. Pitani kuchipatala msanga

Njira zotetezera moto za methyl 2,2-difluorobenzo[d][1,3]dioxole-5-carboxylate ndi motere:

• Chozimitsa moto: Zimitsani moto ndi nkhungu yamadzi, ufa wouma, thovu kapena chozimitsa cha carbon dioxide. Pewani kugwiritsa ntchito madzi oyenda mwachindunji kuzimitsa moto, zomwe zingayambitse kudontha kwa madzi oyaka ndi kuyatsa moto.

• Zowopsa zapadera: Palibe deta yomwe ilipo

• Njira zodzitetezera pamoto: Ozimitsa moto ayenera kuvala zida zopumira mpweya, kuvala zovala zonse zomwe zimayaka moto, komanso kulimbana ndi mphepo yamkuntho. Ngati ndi kotheka, chotsani chidebecho kuchokera pamoto kupita pamalo otseguka. Zotengera zomwe zili pamalo ozimitsa moto ziyenera kuchotsedwa nthawi yomweyo ngati zasintha kapena kutulutsa mawu kuchokera pachida chothandizira chitetezo. Patulani malo a ngozi ndi kuletsa anthu osayenera kulowamo. Khalani ndi kuthira madzi amoto kuti mupewe kuipitsidwa kwa chilengedwe

Mapeto

Methyl 2,2-difluorobenzo[d] [1,3]dioxole-5-carboxylate ndi gawo lapakati pakupanga mankhwala, kupanga zinthu zoteteza mbewu, komanso kafukufuku wasayansi. Ili ndi mawonekedwe apadera okhala ndi maatomu awiri a fluorine ndi gulu la carboxylate lomwe limalumikizidwa ndi mphete ya benzodioxole, yomwe imapereka kukhazikika, kuchitapo kanthu, lipophilicity, ndi bioavailability kumaguluwo. Imakhala ndi kusungunuka kwamadzi otsika komanso kuthamanga kwa nthunzi, komanso malo otentha ocheperako komanso malo ong'anima. Imaikidwa ngati chinthu chowopsa ndipo imafuna kugwiridwa bwino ndi kusungidwa. Itha kugwiritsidwa ntchito m'mafakitale osiyanasiyana, monga mankhwala, agrochemicals, kafukufuku, ndi ena.

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