Ntchito Zofunikira za Modified Nucleosides

Mawu Oyamba

Nucleosides, the building blocks of nucleic acids (DNA and RNA), play a fundamental role in all living organisms. Posintha mamolekyuwa, asayansi atsegula njira zambiri zomwe zingagwiritsidwe ntchito pofufuza ndi zamankhwala. M'nkhaniyi, tiwona zina mwazofunikira zama nucleosides osinthidwa.

Ma nucleosides osinthidwa amapangidwa mwa kusintha kapangidwe ka nucleosides zachilengedwe, monga adenosine, guanosine, cytidine, ndi uridine. These modifications can involve changes to the base, sugar, or both. The altered structure can impart new properties to the modified nucleoside, making it suitable for various applications.

Mapulogalamu Ofunika Kwambiri

Antiviral agents: Ma nucleosides osinthidwa amagwiritsidwa ntchito popanga mankhwala oletsa ma virus omwe angalepheretse kuchulukitsa kwa ma virus. The most famous example is the use of modified nucleosides in COVID-19 mRNA vaccines.

Antibacterial agents: Ma nucleosides osinthidwa awonetsanso kudalirika popanga mankhwala atsopano.

Genetic Engineering:

Kukhazikika kwabwino: Ma nucleosides osinthidwa amatha kukulitsa kukhazikika kwa ma nucleic acid, kuwapangitsa kukhala osagwirizana ndi kuwonongeka ndi ma enzyme.

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