7-Amino-3-cephem-4-carboxylic acid
Zambiri Zoyambira:
Dzina lachingerezi:
7-ANCA;7-AMOCA;(6R,7R)-7-AMino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicAcid;7-NACA;7- NACA,7-ANCA;7-ANCAChemicalbookimpurity;CeftizoximeImpurity9;CeftizoximeImpurity16;Ceftizoximeintermediate(7-anca);7-amino-3-cephem-4-carboxylicacid
Nambala ya CAS: 36923-17-8
Mapangidwe a maselo: C7H8N2O3S
Molecular kulemera: 200.21
Nambala ya EINECS: 609-312-7
Zomangamanga:
Zogwirizana ndi magulu: Organic intermediates; Mankhwala apakatikati; Zopangira mankhwala.
Malo osungunuka: 215-218 ° C
Malo otentha: 536.9±50.0 °C (Zonenedweratu)
Kachulukidwe: 1.69± 0.1g /cm3 (Zonenedweratu)
Refractive index: 1.735 (kuyerekeza)
Pothirira: 278.508°C
Kusungunuka: Kusungunuka mu acidic aqueous solution (pang'ono, kutentha), DMSO (pang'ono). Katundu: ufa woyera kapena woyera crystalline.
Kuthamanga kwa nthunzi: 0mmHg pa 25°C
| kufotokoza | unit | muyezo |
| Maonekedwe | White kapena woyera crystalline ufa | |
| Zomwe zili zofunika kwambiri | % | ≥98.5% |
| Chinyezi | % | ≤1 |
| Mono hybrid | % | ≤0.5 |
| Zochuluka | % | ≤1 |
Cephalosporin amagwiritsidwa ntchito ngati wapakatikati wa cefbutan ndi cefazoxime.
sulfuric acid (104.3mL, 1.92mol) idawonjezeredwa m'mabotolo atatu, kenako isophthalic acid (40g, 0.24mol) idawonjezedwa, kusonkhezeredwa ndikutenthedwa mpaka 60 ℃, yomwe inachitikira 0.5h, ndi 60% nitric acid (37.8g, 0.36) mol) idawonjezedwa kuti iwongolere kuchuluka kwa madontho. Onjezani mu maola awiri. Pambuyo powonjezera, kutentha kusungirako ku 60 ℃ kwa maola awiri. Kuzizira mpaka pansi pa 50 ° C, kenaka yikani 100mL yamadzi. Zinthuzo zinali utakhazikika kutentha kwa firiji, anatsanulira mu fyuluta, amapopedwa kuchotsa zinyalala asidi, keke fyuluta anatsukidwa ndi madzi, chatsanulidwa kuti recrystallize, ndi mankhwala woyera anali 34,6 magalamu, zokolola anali 68,4%.
20Kg kapena 25Kg/ ndowa, chidebe cha makatoni, chokhala ndi wosanjikiza woyera ndi thumba lakuda la polyethylene. 2 ℃-8 ℃ youma, malo ozizira, kutali ndi kusungirako kuwala, zomveka kwa zaka 2.
