2-methyl-5-nitroimidazole
Zambiri Zoyambira:
Dzina la mankhwala: 2-methyl-5-nitroimidazole;
Dzina lachingerezi: 2-Methyl-5-nitroimidazole;
Nambala ya CAS: 88054-22-2
Molecular formula: C4H5N3O2
Kulemera kwa molekyulu: 127.1
Nambala ya EINECS: 618-108-7
Zomangamanga:
Magulu okhudzana: zopangira; Mankhwala apakatikati; Zopangira mankhwala.
Kachulukidwe: 1.4± 0.1g /cm3
Malo otentha: 399.5±15.0 °C pa 760 mmHg
Malo osungunuka: 252-254ºC
Kung'anima :195.4±20.4 °C
Kulemera kwake: 127.038177
PSA: 74.50000 LogP: -0.10
Maonekedwe: Mwala woyera
Kuthamanga kwa nthunzi: 0.0±0.9 mmHg pa 25°C
Refraactive index: 1.592
Malo osungira: osindikizidwa pamalo ozizira komanso owuma a 0-6 ºC
Kukhazikika: sichidzawonongeka ikagwiritsidwa ntchito ndikusungidwa motsatira malamulo.
| kufotokoza | unit | muyezo |
| Maonekedwe | Monga ufa woyera kapena wachikasu | |
| Zamkatimu | % | ≥99% |
| Chinyezi | % | ≤0.3 |
| Sulphate | % | ≤0.3 |
Makamaka ntchito synthesis wa metronidazole, dimetazole ndi mankhwala intermediates.
Amapezeka ndi nitration ya 2-methylimidazole. Ikani sulfuric acid, 2-methylimidazole ndi sodium sulfate mumphika momwe, chipwirikiti ndi kutentha, onjezerani asidi wa nitric pa 150-160 ℃, onjezerani, tsatirani bokosilo kwa ola limodzi. Chotsani kutentha kwa 140 ℃ pansipa, mutawonjezera madzi ndi ammonia madzi kuti musinthe pH kukhala 3.5-4, crystallization. Kupsyinjika, kusamba kuti asalowerere, owuma, 2-methyl-5-nitroimidazole.
25k kraft pepala thumba kapena thumba nsalu (58 × 110) alimbane ndi thumba pulasitiki, 250kg katundu chidebe thumba (100 × 80); Malinga ndi zofuna za makasitomala;
Zosungirako zosindikizidwa, zosungidwa m'malo ozizira, amdima, owuma, kusungirako ndi zoyendera ziyenera kukhala zopepuka, kuteteza kuwonongeka ndi chinyezi, zoletsedwa ndi mankhwala osokoneza bongo.
Njira yopangira: Imapezeka ndi nitration ya 2-methylimidazole. Ikani sulfuric acid, 2-methylimidazole ndi sodium sulfate mumphika momwe, chipwirikiti ndi kutentha, onjezerani asidi wa nitric pa 150-160 ℃, onjezerani, tsatirani bokosilo kwa ola limodzi. Chotsani kutentha kwa 140 ℃ pansipa, mutawonjezera madzi ndi ammonia madzi kuti musinthe pH kukhala 3.5-4, crystallization. Kupsyinjika, kusamba kuti asalowerere, owuma, 2-methyl-5-nitroimidazole.
